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M9550187.TXT
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1995-03-04
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Document 0187
DOCN M9550187
TI The duration of breastfeeding by HIV-1-infected mothers in developing
countries: balancing benefits and risks.
DT 9505
AU Nagelkerke NJ; Moses S; Embree JE; Jenniskens F; Plummer FA; Department
of Medical Microbiology, University of Nairobi, Kenya.
SO J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):176-81.
Unique Identifier : AIDSLINE MED/95135995
AB How best to advise mothers infected with human immunodeficiency virus
type 1 (HIV-1) in developing countries regarding breastfeeding is an
important issue that has generated considerable debate. Previous studies
have addressed this problem by means of mathematical models, but without
considering the issue of the duration of breastfeeding. A mathematical
model was developed to compare the age-specific risks of mother-to-child
HIV transmission versus the excess mortality due to not breastfeeding.
In this model it is assumed that both the risk of mother-to-child
transmission of HIV through breast milk and the relative risk of not
breastfeeding do not vary with age. The model indicates that, in
HIV-1-seropositive mothers, the decrease in child mortality afforded by
breastfeeding may exceed the risk of mother-to-child HIV-1 transmission
only during the first 3-7 months of life. Thereafter the risk of HIV-1
transmission probably exceeds the mortality benefit of breastfeeding.
Experimental studies of counselling HIV-1-infected mothers to limit
their duration of breastfeeding should be considered in the setting of
developing countries.
DE *Breast Feeding *Developing Countries *Disease Transmission, Vertical
Female Human HIV Infections/EPIDEMIOLOGY/*TRANSMISSION Infant
Infant, Newborn *Models, Biological Pregnancy Risk Factors Support,
Non-U.S. Gov't Time Factors JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).